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心力衰竭是各种心脏疾病的终末阶段.近年来研究发现,心力衰竭本质是一种炎性反应,在心力衰竭的发展中,促炎因子如肿瘤坏死因子、白介素-6、白介素-1β通过影响心脏以及血液循环进一步加重心力衰竭的疾病进展.同时,微小RNAs(miRNAs)被人们证实,在肿瘤以及心血管病等方面,可以减轻疾病进展中的炎性反应过程.然而,miRNAs在心力衰竭发展中对炎性反应的影响研究甚少,为此,现总结miRNAs与心力衰竭炎性反应的关系,进一步探究miRNAs能否延缓心力衰竭的发展进程.“,”Heart failure is the end stage of various cardiac diseases.Recent studies have found that heart failure is the essence of an inflammatory response in the development of heart failure, pro-inflammatory cytokines such as tumor necrosis factor, interleukin-6, interleukin-1βby affecting the heart and blood circulation disease lead to further aggravate heart failure. At the same time,micro RNAs ( miRNAs) been demonstrated in tumor and cardiovascular disease, it can reduce disease pro-gression of the inflammatory response.However, miRNAs influence the development of heart failure in the study of inflamma-tory response in very minor way, therefore, inflammatory response relationship between miRNAs and heart failure are summa-rized, further explore whether miRNAs can delay the process of development of heart failure.