Near-infrared Aza-BODIPY Dyes Through Molecular Surgery for Enhanced Photothermal and Photodynamic A

• 作 者: YU Qing HUANG Xuan ZHANG Tian WANG Weili YANG Dongliang SHAO Jinjun DONG Xiaochen
• 机 构: Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM),Nanjing Tech Univ
• 出 处: 高等学校化学研究（英文版）
• 发表日期: 2021年4期
• 关键词: Aza-dipyrromethene boron difluoride(aza-BODIPY) Photothermal therapy Photodynami

The widespread use of high-dose antibiotics will not only lead to the rapid acquisition of antibiotic resistance and increased incidence of drug-resistant bacterial infections,but also produce toxic side effects on normal tissues.Herein,two near-infrared dyes BDP-4PTZ and BDP-4DPA were synthesized,and the electron donors of diphenylamine and phenothiazine with the only difference of sulphur(S)-lock between the two phenyl rings were introduced onto the electron acceptor aza-dipyrromethene boron difluoride(aza-BODIPY)through molecular surgery.Through co-precipitation into nanoparticles(NPs),BDP-4PTZ NPs and BDP-4DPA NPs were fabricated with good biocompatibility.Upon 660 nm photoirradiation,BDP-4PTZ NPs and BDP-4DPA NPs showed excellent photothermal conversion efficiency(43％and 50％,respectively)and reactive oxygen species(ROS)production performance(ca.3.6 and 6 times higher than that of indocyanine green,respectively).In vitro antibacterial experiments indicated that both NPs could effectively destroy the bacteria\'s membrane to eradicate drug-resistant bacteria.Furthermore,the bacterial abscess was effectively eliminated after treatment with BDP-4DPA NPs under 660 nm photoirradiation without adverse effects.Thus,through molecular surgery,BDP-4DPA without the S-lock demonstrates synergistic photothermal and photodynamic antimicrobial activities,which is promising for further molecular design towards effective neo-antimicrobial phototherapy.