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目的:探讨醒脑静注射液和纳洛酮联用治疗急性一氧化碳(CO)中毒的疗效。方法:将我院2013年10月—2016年1月收治60例急性CO中毒患者随机平均分为常规治疗组和联合用药组,所有患者入院后高流量吸氧行生命体征监测、血常规、心电图、肝肾功、随机血糖、头颅CT(心、肺呼吸保驾下)排除脑血管意外等辅助检查,常规治疗组采取利尿、保肝、利液治疗。联合用药组在常规治疗的基础上,采用纳洛酮(0.8~2)mg加入5%葡萄糖溶液250mL中静脉滴注;同时采用醒脑静注射液(10~20)mL加入5%葡萄糖溶液250mL中静脉滴注,对两组的治疗效果及苏醒时间进行分析。结果:随访3个月,联合用药组发生迟发性脑病0例,常规治疗组发生迟发型脑病5例。两组患者痊愈率差异有统计学意义(P<0.05)。常规治疗组苏醒时间为(2~6)小时,平均(3.7±2.3)小时。联合用药组苏醒时间为(1~4)小时,平均(2.4±0.9)小时,显著短于常规治疗组(P<0.05)。结论:纳洛酮及醒脑静联合应用对急性CO中毒具有见效快、苏醒时间短、减少迟发性脑病、后遗症较少的优点,是临床上治疗急性CO中毒较好的方法。
Objective: To investigate the effect of xingnaojing injection combined with naloxone in the treatment of acute carbon monoxide (CO) poisoning. Methods: A total of 60 patients with acute CO poisoning who were admitted to our hospital from October 2013 to January 2016 were randomly divided into routine treatment group and combination group. All patients were admitted to hospital with high-flow oxygen inhalation vital signs monitoring, blood routine, electrocardiogram , Liver and kidney function, random blood sugar, cranial CT (heart, lungs under the escort) to exclude cerebrovascular accident and other auxiliary examination, conventional treatment group to take diuretic, liver, Li liquid therapy. On the basis of routine treatment, the combination group was treated with naloxone (0.8 ~ 2) mg into 250mL 5% dextrose solution for intravenous infusion. At the same time, 250mL of 5% dextrose solution In the intravenous drip, the two groups of treatment and recovery time analysis. Results: Followed up for 3 months, 0 cases of delayed encephalopathy occurred in combination group and 5 cases of delayed encephalopathy in conventional treatment group. There was significant difference between the two groups in the cure rate (P <0.05). The recovery time of routine treatment group was (2 ~ 6) hours, with an average of (3.7 ± 2.3) hours. The recovery time of combination group was (1 ~ 4) hours, with an average of (2.4 ± 0.9) hours, which was significantly shorter than that of the conventional treatment group (P <0.05). Conclusion: The combination of naloxone and xingnaojing has the advantages of quick response, short recovery time, less delayed encephalopathy and less sequelae in acute CO poisoning. It is a good method to treat acute CO poisoning clinically.