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目的观察5-FU行中晚期胃肠道肿瘤术后腹腔灌注联合静脉双途径化疗与单纯静脉化疗对肝、腹膜转移的疗效。方法将胃肠道肿瘤术后确诊为侵及浆膜层的患者随机分为2组,每组30例。腹腔灌注组:给予5-FU腹腔灌注结合FolFoxIV方案双途径给药。对照组:只给予FolFoxIV方案静脉化疗,随访2年观察转移率。结果治疗组转移率13.3%,对照组转移率30%。治疗组近期疗效明显提高且具有统计学意义(P<0.05),两组治疗期间血常规、肝肾功能、胃肠道反应、末梢神经等毒性无统计学意义(P>0.05)。结论腹腔灌注联合静脉双途径化疗对侵及浆膜层的胃肠道肿瘤能最大限度减灭肿瘤细胞,从而使近期转移率明显下降。
Objective To observe the effect of peritoneal perfusion combined with intravenous dual-channel chemotherapy and simple intravenous chemotherapy on the metastasis of liver and peritoneum in 5-FU patients with advanced gastrointestinal cancer. Methods The patients diagnosed as invasive and serosa after gastrointestinal cancer were randomly divided into two groups (n = 30 in each group). Peritoneal perfusion group: Intraperitoneal infusion of 5-FU combined with FolFox IV regimen was administered by dual routes. Control group: FolFoxIV only given intravenous chemotherapy, follow-up of 2 years observed metastasis rate. Results The metastasis rate was 13.3% in the treatment group and 30% in the control group. The curative effect of the treatment group was significantly improved and statistically significant (P <0.05). There was no significant difference in blood routine, liver and kidney function, gastrointestinal reaction and peripheral nerve between the two groups during treatment (P> 0.05). Conclusion Intraperitoneal perfusion combined with intravenous dual-route chemotherapy can minimize tumor cells invaded and serosal gastrointestinal tumors, resulting in a significant decrease in recent metastasis rate.