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目的:观察斑蝥酸钠维生素B6注射液联合EP方案化疗治疗广泛期小细胞肺癌的疗效、毒副反应、生活质量的变化。方法:将40例广泛期小细胞肺癌患者按照治疗方案不同随机分为两组:对照组单纯接受EP方案化疗,治疗组在化疗同时联合应用斑蝥酸钠维生素B6注射液。结果:两组近期疗效(CR+PR)分别为70%和60%,差异无统计学意义(P>0.05),B组毒副反应发生率低于A组(P<0.05),在生活质量改善方面两组差异有统计学意义(P<0.05)。结论:斑蝥酸钠维生素B6注射液可减轻化疗毒副反应,有利于改善患者生活质量。
Objective: To observe the curative effect, side effects and quality of life of cantharidate sodium vitamin B6 injection and EP regimen in treatment of extensive stage small cell lung cancer. Methods: Forty patients with extensive-stage small-cell lung cancer were randomly divided into two groups according to different treatment regimens: the control group received only EP regimen chemotherapy, and the treatment group combined chemotherapy with sodium cantharidinate vitamin B6 injection. Results: There was no significant difference in CR + PR between the two groups (P> 0.05). The incidence of side effects in group B was lower than that in group A (P <0.05) The difference between the two groups was statistically significant (P <0.05). Conclusion: Sodium cantharidin vitamin B6 injection can reduce the side effects of chemotherapy and improve the quality of life of patients.