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目的:分析葛根素注射液联合丁苯肽治疗脑梗塞的临床效果。方法:纳入2014年2月-2015年1月于本院就诊的脑梗塞患者64例,随机分为对照组与观察组各32例,对照组予以常规治疗,观察组在此基础上加用葛根素注射液联合丁苯酞治疗,比较两组的临床疗效、不良反应以及血液流变学指标变化情况。结果:(1)观察组的治疗总有效率为93.75%,与对照组的68.75%相比有显著升高,差异具有统计学意义(P<0.05);(2)经治疗后,观察组的全血黏度以及纤维蛋白质原分别为(3.04±0.36)m Pa/s、(1.59±0.31)g/L,与对照组水平相比下降明显,且观察组的红细胞压积更高,差异具有统计学意义(P<0.05);(3)观察组与对照组的不良反应率分别为18.75%、21.87%,差异无统计学意义(P>0.05),均在对症处理后恢复正常。结论:葛根素注射液与丁苯肽联合治疗脑梗塞的临床效果确切,安全可靠。
Objective: To analyze the clinical effect of puerarin combined with diphenylethanil in the treatment of cerebral infarction. Methods: A total of 64 patients with cerebral infarction who were treated in our hospital from February 2014 to January 2015 were randomly divided into control group and observation group, 32 cases in each group. The control group was treated routinely. The observation group was given Pueraria Su-injection combined with butylphthalide treatment, the two groups were compared the clinical efficacy, adverse reactions and changes in hemorheology indicators. Results: (1) The total effective rate of the observation group was 93.75%, which was significantly higher than that of the control group (68.75%), the difference was statistically significant (P <0.05); (2) After treatment, The whole blood viscosity and fibrinogen were (3.04 ± 0.36) m Pa / s and (1.59 ± 0.31) g / L, respectively, which were significantly lower than those in the control group, and the hematocrit of the observation group was higher (P <0.05). (3) Adverse reaction rates in observation group and control group were 18.75% and 21.87%, respectively, with no significant difference (P> 0.05). All of them returned to normal after symptomatic treatment. Conclusion: The combination of puerarin and NBP is effective and safe in treating cerebral infarction.