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目的观察急性脑梗死患者血液糖化血红蛋白(GHbAlc)的浓度变化及其与脑梗死患者神经功能缺损程度评分之间的关系。方法采用高效液相离子交换层析法检测60例病程在1周之内的急性脑梗死患者和30例健康对照组血液GHbAlc水平;按照中国卒中量表对全部脑梗死患者于入院当天进行神经功能缺损程度评分,并将脑梗死患者分为轻、中、重三组。结果脑梗死患者血液GHbAlc水平明显升高,与对照组比较有统计学意义(P<0.01);男女性别比较血液GHbAlc含量无统计学意义。脑梗死患者轻、中、重三组间血液GHbAlc含量存在统计学意义(F=26.273,P<0.01);脑梗死组神经功能缺损程度评分与血液GH-bAlc水平呈正相关(r=0.478,P<0.05)。结论GHbAlc可能是脑梗死的危险因素之一,血液GHbAlc水平越高病情越重,提出可以将血液GHbAlc水平作为预测脑梗死患者病情轻重的指标之一。
Objective To observe the changes of blood glycosylated hemoglobin (GHbAlc) in patients with acute cerebral infarction and its relationship with the score of neurological deficits in patients with cerebral infarction. Methods High-performance liquid chromatography-ion exchange chromatography was used to detect the serum levels of GHbAlc in 60 patients with acute cerebral infarction within one week and 30 healthy controls. All patients with cerebral infarction were assessed for neurological function on the day of admission according to the Chinese Stroke Scale The degree of defect score, and patients with cerebral infarction is divided into light, medium and heavy three groups. Results The blood levels of GHbA1c in patients with cerebral infarction were significantly higher than those in the control group (P <0.01). There was no significant difference in the blood GHbA1c levels between men and women. The levels of GHbA1c in the three groups were statistically significant (F = 26.273, P <0.01). There was a positive correlation between the levels of GH-bAlc and the levels of GH-bAlc in cerebral infarction group (r = 0.478, P <0.05). Conclusions GHbA1c may be one of the risk factors of cerebral infarction. The higher the level of GHbA1c in blood, the more serious the disease is. It is suggested that GHbA1c can be used as a predictor of severity of cerebral infarction.