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本文作者1980年曾报告说,粒细胞输注期间败血症持续存在或者因而致命的原因,与存在有预先形成的粒细胞抗体有关。本文是上述初步报告的续篇。患者系美国费城儿童医院和宾夕法尼亚大学医院3年内以及费城坦普尔大学医院1年内接受过粒细胞输注者。所有患者均为白血病和再生障碍性贫血病人,确诊前无败血症征象。输注粒细胞的标准是:粒细胞数少于500/μl,和有感染证据而用抗生素包括氨基糖甙(一种半合成青霉素)和先锋霉素治疗无效者。输注停止的标准是出现下列情况之一时,临床败血症消退而且血培养阴性,粒细胞数上升达500/μl,或死亡。
The authors reported in 1980 that the reason for the persistence or fatality of sepsis during granulocyte transfusion was associated with the presence of preformed granulocyte antibodies. This article is a continuation of the initial report. The patients were treated by the Philadelphia Children’s Hospital and the University of Pennsylvania Hospital within three years and the Temple University Hospital in Philadelphia within one year of receiving granulocyte transfusion. All patients were leukemia and aplastic anemia, signs of sepsis prior to diagnosis. The criteria for infusing granulocytes are: less than 500 / μl of granulocytes, and evidence of infection that is ineffective with antibiotics, including aminoglycosides (a semisynthetic penicillin) and cephalosporin. Infusion stops when one of the following conditions occur: clinical sepsis subsides and blood cultures become negative with an increase in the number of granulocytes of 500 / μl, or death.