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Background. Mucosa-associated lymphoid tissue (MALT) lymphoma involving multi ple organs is not well characterized. Methods. To obtain a better understanding of gastric MALT lymphoma with multiple organ involvement, we compared Helicobact er pylori infection status; response to eradication therapy; prevalence of genet ic abnormality, including t(11;18)-(q2l;q2l); and clonality of tumor cells betw een patients with gastric MALT lymphoma with and without multiple organ involvem ent. Results. Of 54 patients with only gastric involvement, 51 were positive for H. pylori (94.4%), whereas only 3 of 9 patients with multiple organ involvemen t had the infection (33.3%). Among those who received eradication therapy, the remission rate in patients with only gastric involvement was significantly highe r than that in patients with multiple organ involvement (71.4%vs 33.3%; P < 0. 05). The positive rate of AP12-MALT1 fusion transcripts was significantly great er in patients with multiple lesions with either single or multiple organ involv ement than in those with a single gastric lesion (71.4%vs 12.5%; P < 0.05), bu t 2 of 2 patients with multiple gastric lesions had the fusion transcripts. Of 5 patients with multiple organ involvement tested for clonality of the CDR3 regio n, distinct clones were detected in lymphoma lesions in different organs in 3 pa tients, whereas the identical clone was present in the different lesions in the remaining 2 patients. Conclusions. Gastric MALT lymphoma with multiple organ inv olvement is often associated with API2-MALT1 fusion transcripts. Moreover, H. p ylori infection is rare in patients with multiple organ involvement as compared to those with only gastric involvement. Patients with gastric MALT lymphoma with multiple organ involvement who are positive for H. pylori are resistant to erad ication therapy.
Background. Mucosa-associated lymphoid tissue (MALT) lymphoma with multi ple organs is not well characterized. Methods. To obtain a better understanding of gastric MALT lymphoma with multiple organ involvement, we compared Helicobactor pylori infection status; response to eradication therapy; prevalence of genet ic abnormality, including t (11; 18) - (q21; q21); and clonality of tumor cells with een patients with gastric MALT lymphoma with and without multiple organ involvement were positive for H. pylori (94.4%), only 3 of 9 patients with multiple organ involvement had t had the infection (33.3%). Among those who received eradication therapy, the remission rate in patients with only gastric involvement was significantly highe r than that in patients with multiple organ involvement (71.4% vs 33.3%; P <0.05). The positive rate of AP12-MALT1 fusion transcripts was significantly greater in patients with multiple lesions wit h either single or multiple organ involvment than in those with a single gastric lesion (71.4% vs 12.5%; P <0.05), bu t 2 of 2 patients with multiple gastric lesions had the fusion transcripts. Of 5 patients with multiple organ involvement tested for clonality of the CDR3 regio n, distinct clones were detected in lymphoma lesions in different organs in 3 pa tients, whereas the identical clone was present in the different lesions in the remaining 2 patients. Conclusions. Gastric MALT lymphoma with multiple organ involvement is often associated with API2-MALT1 fusion transcripts. Moreover, H. p ylori infection is rare in patients with multiple organ involvement as compared to those with only gastric involvement. Patients with gastric MALT lymphoma with multiple organ involvement who are positive for H. pylori are resistant to erad ication therapy.