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目的研究根除治疗前后幽门螺杆菌在胃内的分布特点．方法有消化道症状，Ｈｐ＋慢性胃炎患者９０例，其中男５２例，女３８例，年龄１９岁～７４岁，平均４４岁．采用ＣＢＳ，ＦｕＺ，Ｍｅｔ三联治疗２ｗｋ，在根除治疗前及治疗结束４ｗｋ后从胃底、胃体、角切迹、幽门前大弯侧多部位取活检，以ＷａｒｔｈｉｎＳｔａｒｙ染色检测Ｈｐ，ＨＥ染色观察局部胃炎程度．结果三联治疗前Ｈｐ呈全胃分布，各部位Ｈｐ阳性率无明显差异（Ｐ＞００５），但Ｈｐ数量和胃炎程度各部位有差异，且有明显相关性（ｒ＝０９４８），以角切迹Ｈｐ数量最多，胃炎程度最重，局灶性萎缩、活动性胃炎的发生率亦最高．２２例根除治疗后Ｈｐ仍阳性患者，以胃底检出率最高（９０９％），角切迹最低（３１８％），两部位相比有显著差异（χ２＝１４４，Ｐ＜００１）．结论角切迹是治疗前Ｈｐ的最佳检测部位，胃底是治疗后Ｈｐ的最佳检测部位．
Objective To study the distribution of Helicobacter pylori in the stomach before and after eradication therapy. Method of gastrointestinal symptoms, Hp + 90 cases of chronic gastritis, including 52 males and 38 females, aged 19 years to 74 years, mean 44 years. CBS, FuZ, Met triple therapy 2wk, before eradication therapy and 4wk after the end of treatment from the fundus, corpus, angle notch, pyloric curvature of the multi-site biopsy to Warthin Stary staining Hp, HE staining observed Local gastritis. Results Before treatment, Hp showed a whole stomach distribution with no significant difference in Hp positive rate (P> 0.05), but there was significant difference between Hp and gastritis (r = 0.948) The highest number of angle notch Hp, the degree of gastritis, focal atrophy, the highest incidence of active gastritis. Twenty-two patients with Hp still positive after eradication treatment showed the highest detection rate of gastric fundus (909%) and lowest (318%) of angular notch, with significant difference between the two sites (χ2 = 144, P < 0 01). Conclusions Angle notch is the best detection site of pre-treatment Hp, and gastric fundus is the best detection site of Hp after treatment.