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生物膜是细菌感染的重要方式,生物膜所致的高度耐药性已经越来越威胁到人类健康。鞭毛在生物膜形成中的重要性已经被医学界广泛接受,普遍认为鞭毛的运动性与生物膜的形成能力成正比。然而,近年来多项研究表明,并非所有细菌的鞭毛都促进生物膜的形成,在环二核苷酸等分子作用下抑制细菌鞭毛的合成和运动性后,细菌生物膜的合成和稳定性显著增强。
Biofilms are an important way of bacterial infections. The high resistance caused by biofilms has become increasingly threatening to human health. The importance of flagella in biofilm formation has been widely accepted by the medical community and it is generally accepted that the mobility of flagella is directly proportional to the ability of the biofilm to form. However, in recent years, a number of studies have shown that not all bacterial flagella promote the formation of biofilm, and the synthesis and stability of bacterial biofilms are significantly inhibited after the inhibition of the synthesis and motility of bacterial flagella by cyclic dinucleotide and other molecules Enhanced.