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作者应用盐酸钠洛酮治疗38例脑梗死患者并以丹参治疗组作为对照，进行对比研究，结果纳格酮治疗组有效率89％，丹参组有效率64％，两者比较，存在着差异（P＜0．05）。提示早期合理使用盐酸钠洛酮（内源性吗啡样物质拮抗剂），可减轻、阻止甚至逆转由β-内啡肽所造成的局部脑缺血、水肿、梗死性病理过程．防止神经缺血性损害扩展。脑梗死发病24小时内使用纳洛酮，有效率90％。纳格酮始用量1．2mg·日-1·次-1，大剂量3．2mg·日-1·次-1，起效快，安全范围大，疗效高、毒副作用小，推荐用于脑梗死治疗的有效药物，值得在急诊推广应用。
The authors applied 38 patients with cerebral infarction treated with sodium hydrocodone hydrochloride and compared them with the control group. The results showed that the effective rate was 89% in the naloxone treatment group and 64% in the radix salviae miltiorrhizae group, with the difference between the two P <0.05). Prompt rational use of early sodium hydrocodone hydrochloride (endogenous morphine-like antagonists), can reduce, prevent or even reverse the local cerebral ischemia caused by β-endorphin, edema, infarction pathological processes. Prevent neuronal ischemic damage from expanding. Naloxone within 24 hours of onset of cerebral infarction, the effective rate of 90%. The dosage of nalgone 1.2mg · day -1 · -1 times, high dose 3.2mg · day -1 · times -1, rapid onset, large safety range, high efficacy, side effects, recommended for brain Effective treatment of infarction, it is worth to promote the application of emergency.