论文部分内容阅读
目的探讨芬太尼透皮贴剂(transdermal fentanyl,TDF)治疗癌性疼痛(癌痛)的疗效、不良反应和对患者生活质量改善的程度。方法观察118例肿瘤晚期癌痛患者使用TDF进行止痛治疗的效果,并进行止痛疗效和生活质量改善的评价,观察不良反应的发生率、严重程度及应对措施。结果118例癌痛患者止痛效果达到完全缓解61例(51.7%),部分缓解48例(40.7%),微效7例(5.9%),无效2例(1.7%),总有效率92.4%。不良反应发生率低,常见的是恶心呕吐(24.6%)和便秘(22.0%);生活质量得到改善,由于疼痛症状消失,部分患者可继续接受原发病的治疗。结论TDF是目前治疗癌痛使用方便、疗效肯定、不良反应较轻的镇痛药,其经皮肤给药的特性易于被患者及家属接受,也为患者治疗原发病赢得了宝贵的时间。
Objective To investigate the efficacy and adverse reactions of fentanyl transdermal fentanyl (TDF) in the treatment of cancer pain (cancer pain) and the extent of its improvement on patients’ quality of life. Methods 118 cases of advanced cancer patients with cancer pain using TDF analgesic effect were observed, and analgesic efficacy and quality of life of the evaluation, to observe the incidence of adverse reactions, the severity and coping strategies. Results In 118 cases of cancer pain patients, 61 patients (51.7%) achieved complete pain relief, 48 patients (40.7%) were partially relieved, 7 patients (5.9%) were ineffective and 2 patients (1.7%) were ineffective. The total effective rate was 92.4%. The incidence of adverse reactions is low, common nausea and vomiting (24.6%) and constipation (22.0%); quality of life improved, due to the disappearance of pain symptoms, some patients may continue to receive the treatment of the primary disease. Conclusion TDF is currently used in the treatment of cancer pain with ease, efficacy and less adverse reactions to analgesics. The transdermal drug delivery characteristics of TDF are easily accepted by patients and their families, and have gained valuable time for the treatment of primary disease.