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目的 探讨放射性胶体3 2 磷 ( 3 2 P)治疗胰腺癌的疗效。方法 将胰腺癌细胞株SW 1990接种于裸鼠皮下 ,待肿瘤生长直径达 ( 1 2± 0 2 )cm时 ,按每立方厘米瘤体积不同剂量的3 2 P分为空白对照组、5 -FU组、联合组、3 2 P(B)组及3 2 P(A)组进行实验 ,在治疗后 2周测量肿瘤大小 ,计算肿瘤缩小率及肿瘤坏死率。结果 治疗 2周后各组的肿瘤缩小率分别为 - 15 5 19%、12 81%、36 5 7%、44 73%、45 2 0 % (各组与对照组比较P <0 0 5 ) ,肿瘤坏死率分别为 9 12 %、17 6 6 %、2 7 6 4%、45 0 2 %、6 1 72 % (各组与对照组比较P <0 0 5 )。结论 胶体3 2 P肿瘤间质内注射对胰腺癌是一种介入放射肿瘤学有效的治疗方法 ,最佳剂量范围应在 18 5～ 37MBq/cm3 之间 ,临床实验正在逐步进行中。
Objective To investigate the effect of radioactive colloidal 3 2 phosphorus (3 2 P) in the treatment of pancreatic cancer. Methods The pancreatic cancer cell line SW1990 was inoculated subcutaneously in nude mice. When the diameter of the tumor reached (1 2 ± 0 2 )cm, 3 2 P in different doses per cubic centimeter of tumor volume was divided into blank control group and 5-FU group. Group, combined group, 3 2 P(B) group and 3 2 P(A) group were subjected to the experiment. Tumor size was measured 2 weeks after treatment, and tumor shrinkage rate and tumor necrosis rate were calculated. Results After 2 weeks of treatment, tumor shrinkage was -15 5 19%, 12 81%, 36 5 7%, 44 73%, 45 2 0 % in each group (P <0 05 in each group compared with the control group). The tumor necrosis rates were 9 12 %, 17 66 %, 276 4 %, 45 0 2 %, and 61 72 %, respectively (P <0 05 in each group compared with the control group). Conclusion Colloidal 3 2 P tumor interstitial injection is an effective method for interventional radiation oncology in pancreatic cancer. The optimal dose range should be between 18 5 and 37 MBq/cm3. Clinical trials are progressing gradually.