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液体混合是微流控芯片的重要功能之一,微流控液体混合方式可分为主动式和被动式两种。针对目前微流控混合器存在的被动式混合效率不高和主动式混合器制作工艺复杂等问题,研究设计了一种基于雕刻机加工的低成本、高效率气动式微流控混合器。该微流控芯片采用数控雕刻机快速加工微模具,经PDMS固化、翻模、打孔和键合等工艺,实现了微流控混合器的制作。同时研究设计了多气室脉冲气体驱动模式,有效实现了微量试剂和样品的快速混合。实验结果表明,所研究的主动式微流控混合器可以产生对流混沌作用,显著提高微尺度下的混合效率,为实现低成本的微流控芯片制作和高效试剂混合的MEMS生化检测系统提供了一种有效的技术途径。
Liquid mixing is one of the important functions of microfluidic chips. Microfluidic liquid mixing methods can be divided into active and passive. Aimed at the problems of passive mixing efficiency and complicated manufacturing process of active mixer, the low cost and high efficiency aerodynamic microfluidic mixer based on engraving machine is studied. The microfluidic chip adopts CNC engraving machine to process micro-molds quickly, and has achieved the production of microfluidic mixer by PDMS curing, mold turning, drilling and bonding. At the same time, a multi-chamber pulse gas driving mode has been designed and designed, which can effectively realize the rapid mixing of trace reagents and samples. The experimental results show that the proposed active microfluidic mixer can produce convective chaos, significantly improve the mixing efficiency at the micro-scale, and provide a MEMS biochemical detection system for low-cost microfluidic chip fabrication and efficient reagent mixing An effective technical approach.