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成纤维细胞生长因子9(fibroblast growth factor 9,FGF9)是成纤维细胞生长因子家族(FGFs)的成员之一。广泛分布于人体各种组织中,它参与骨骼发育、血管形成、胚胎发育、损伤修复、细胞凋亡、神经再生、肿瘤生长等多种生理和病理的过程,可有效促进有丝分裂和细胞生长。研究发现,FGF9不仅在骨骼发育和生长期对软骨形成和成骨生成起着重要的作用,而且对卵巢癌的发生、神经再生、性腺分化等方面也有重要的影响,对FGF9作为一个有用治疗靶点发挥作用的功能和机制仍有待进一步的发现及研究。现针对FGF9的特点,综述了其在表达及适应征机制方面的研究进展,为FGF9进一步的研究及合理开发利用提供参考。
Fibroblast growth factor 9 (FGF9) is a member of the fibroblast growth factor family (FGFs). It is widely distributed in various tissues of the human body. It participates in various physiological and pathological processes such as bone development, angiogenesis, embryonic development, injury repair, apoptosis, nerve regeneration and tumor growth, and can effectively promote mitosis and cell growth. It has been found that FGF9 not only plays an important role in chondrogenesis and osteogenesis but also plays an important role in the occurrence of ovarian cancer, nerve regeneration and gonadal differentiation. FGF9 is a useful therapeutic target Points to play a role in the function and mechanism remains to be further discovered and studied. Now for the characteristics of FGF9, its research progress in the mechanism of expression and indications is reviewed, providing reference for further research and rational development and utilization of FGF9.