论文部分内容阅读
根据卡格列净的结构及合成工艺,制备了可能存在的4个工艺杂质:(1S)-1,5-脱氢-1-C-[3-[(5-苯基-2-噻吩基)-甲基]-4-甲基苯基]-D-葡萄糖醇(有关物质A)、(1R)-1,5-脱氢-1-C-[3-[[5-(4-氟苯基)-2-噻吩基]甲基]-4-甲基苯基]-D-葡萄糖醇(有关物质B)、(2R,3R,4R)-2-[(S)-1,2-二羟基乙基]-5-[3-[[5-(4-氟苯基)-2-噻吩基]甲基]-4-甲基苯基]四氢呋喃-3,4-二醇(有关物质C)及(2S,3R,4R,5R)-1-[3-[[5-(4-氟苯基)-2-噻吩基]甲基]-4-甲基苯基]己烷-1,2,3,4,5,6-六醇(有关物质D),并经MS、~1H NMR和~(13)C NMR等确证结构。
According to the structure and synthesis process of cagonog net, four possible process impurities were prepared: (1S) -1,5-dehydro-1-C- [3 - [ ) -methyl] -4- methylphenyl] -D-glucitol (related substance A), (1R) -1,5-dehydro-1-C- [3 - [[5- (2R, 3R, 4R) -2 - [(S) -1,2-Dichlorobenzyl] Dihydroxyethyl] -5- [3 - [[5- (4-fluorophenyl) -2- thienyl] methyl] -4- methylphenyl] tetrahydrofuran-3,4- diol C) and (2S, 3R, 4R, 5R) -1 - [3 - [[5- (4- fluorophenyl) -2- thienyl] methyl] -4- methylphenyl] , 2,3,4,5,6-hexanol (related substance D), and the structures were confirmed by MS, 1H NMR and 13C NMR.