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Objective The aim of the study was to investigate the clinical features, imaging features, and prognosis of splenium of the corpus callosum in children in order to improve the clinical understanding. Methods The clinical data and imaging data of 30 children with splenium of the corpus callosum treated in Xiamen Children' s Hospital from June 2017 to October 2019 were retrospectively analyzed. Results Thirty children aged from 19 months to 12 years, with an average age of 5. 4 years were included in the study; all had fever and other prodromal infections at acute onset, including 15 cases of respiratory tract infection, 9 cases of digestive tract infection, and 6 cases of central nervous system infection. According to cranial magnetic resonance imaging ( MRI) findings, 23 cases had type I syndrome and 7 cases had type Ⅱ syndrome;23 children had clinical symptoms disappeared after 1 week, 7 children had clinical symptoms disappeared after 1 month, and 23 chil-dren had the abnormal signal disappeared after 2 weeks of reexamination, and the abnormal signal disappeared completely after 1 month of reexamination in 7 children. Conclusion Central nervous system infection is also a predisposing factor for the pressor syndrome of the corpus callosum in children in addition to upper respiratory tract infection and gastrointestinal tract infection, and all children have good prognosis.