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目的:对比研究早晚应用贝那普利治疗高血压的降压效果。方法:将2015年1月至2016年9月于茂名市电白区人民医院接受治疗的高血压患者160例作为研究对象,其中杓型高血压患者和非杓型高血压患者各80例,将杓型高血压患者和非杓型高血压患者分别按照服用时间的不同分为A、B、C、D四组,其中A组和B组为杓型高血压患者,C、D两组均为非杓型高血压,A、C两组于7:00服药,B、D两组于18:00服药。比较杓型高血压患者治疗前后的血压变化情况,并对非杓型高血压患者治疗后血压变化情况进行比较。结果:所有患者治疗前的血压比较,差异均无统计学意义(P>0.05)。经过治疗后A组与B组血压比较,差异无统计学意义(P>0.05),D组的血压明显优于C组,差异具有统计学意义(P<0.05)。结论:18:00服用贝那普利能有效提升非杓型高血压患者的降压治疗效果,对患者的治疗有很大帮助。
OBJECTIVE: To compare the antihypertensive effects of benazepril on hypertension in the morning and evening. Methods: From January 2015 to September 2016, 160 cases of hypertensive patients undergoing treatment in Dianbai People’s Hospital of Maoming City were enrolled. Among them, 80 cases of dipper and 80 cases of non-dipper hypertensive patients Patients with dipper and non-dipper hypertensive patients were divided into four groups A, B, C, D according to the different taking time, in which group A and B were dipper hypertensive patients, C and D groups were Non-dipper hypertension, A, C two groups taking medicine at 7:00, B, D two groups taking medicine at 18:00. The changes of blood pressure in patients with dipper hypertension before and after treatment were compared, and the changes of blood pressure after treatment were compared between non-dipper hypertensive patients. Results: All patients had no significant difference in blood pressure before treatment (P> 0.05). After treatment, there was no significant difference in blood pressure between groups A and B (P> 0.05). The blood pressure of group D was significantly better than that of group C (P <0.05). CONCLUSION: Belaprost at 18:00 can effectively enhance the antihypertensive effect of non-dipper hypertensive patients, which is very helpful for the treatment of patients.