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毛细胞白血病(HCL)占全部白血病患者的2～5%,其发病率约为0.2～0.5/10万。本病的诊断有时十分困难。作者分析了本单位及文献中 HCL 及类似疾病的资料。类似疾病包括慢性淋巴细胞白血病,前淋巴细胞白血病、浆细胞白血病、S(?)zafy 综合征、恶性淋巴瘤(非何杰金淋巴瘤)、恶性组织细胞病、急性单核细胞白血病,慢性单核细胞白血病、骨髓纤维化和再生障碍性贫血。计算各种不同临床表现和实验室资料出现的频率,特别注意了周围血中单核细胞减少的问题,来探讨哪些指标具有早期诊断的意义。结果认为:在全血细胞减少的患者,是本病骨髓牵累的典型表现;外周血单核细胞很少,可为鉴别的要点。在外周血中有很多肿瘤细胞的患者,中性粒细胞及单核细胞减少;肿瘤细胞具有抗酒石酸酸性磷酸酶(TR
Hairy cell leukemia (HCL) accounts for 2 to 5% of all leukemia patients, with a prevalence of about 0.2 to 0.5 / 100,000. The diagnosis of the disease is sometimes very difficult. The authors analyzed data on HCL and similar diseases in this unit and in the literature. Similar diseases include chronic lymphocytic leukemia, pre-lymphocytic leukemia, plasmacytic leukemia, S? Zafy syndrome, malignant lymphoma (non-Hodgkin’s lymphoma), malignant histiocytosis, acute monocytic leukemia, chronic monocytic Myeloid leukemia, myelofibrosis and aplastic anemia. Calculate the frequency of various clinical manifestations and laboratory data, with special attention to the problem of mononuclear cells in peripheral blood to explore which indicators have the significance of early diagnosis. The results showed that: in patients with pancytopenia, the disease is characterized by bone marrow involvement typical; few peripheral blood mononuclear cells can be identified as the main points. Neutrophils and monocytes decreased in patients with many tumor cells in the peripheral blood; the tumor cells had anti-tartaric acid phosphatase (TR