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本研究旨在探讨长期以来无定论的重症肌无力（MG）患者血和脑脊液（CSF）中的乙酰胆碱受体抗体（AChRab）能否与中枢神经元烟碱型乙酰胆碱受体（神经-nAChR）结合，并引起中枢神经系统（CNS）功能障碍。用免疫亲和层析法从AChRab阳性的全身型MG患者血中提取纯化AChRab，然后用免疫组化法探讨AChRab与大鼠中枢神经-nAChR之间的免疫结合反应。结果首次表明，AChRab与神经-nAChR之间的阳性免疫结合反应广泛分布于大鼠大脑皮层、脑干颅神经运动核团、脊髓前角运动神经元等部位，提示MG患者AChRab不仅可与神经肌接头（NMJ）处肌-nAChR结合引起肌无力等症状，还可与CNS神经-nAChR结合，并可能引起CNS功能障碍。
The purpose of this study was to investigate whether acetylcholine receptor antibody (AChRab) in the blood and cerebrospinal fluid (CSF) of chronic myasthenia gravis (MG) patients has long been associated with the central neuronal nicotinic acetylcholine receptor (NerN-nAChR) , And cause central nervous system (CNS) dysfunction. Purified AChRab was extracted from the blood of AChRab positive systemic MG patients by immunoaffinity chromatography. Immunohistochemical method was used to investigate the immunological binding between AChRab and CNS-nAChR in rats. The results showed for the first time that the positive immunoreactive reaction between AChRab and neuronal-nAChR was widely distributed in rat cerebral cortex, brainstem cranial nerve motor nucleus, anterior spinal motor neurons and other parts of the brain, suggesting that patients with MG AChRab not only with neuromuscular Joints (NMJ) Muscle-nAChR binding caused by muscle weakness and other symptoms, but also with the CNS nerve-nAChR binding, and may cause CNS dysfunction.