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目的:探讨纳洛酮联合醒脑静注射液治疗重型颅脑损伤长期昏迷病人的疗效并进行分析。方法:将118例重型颅脑损伤长期昏迷患者随即分为纳洛酮联合醒脑静注射液治疗组(60例)及单独应用纳洛酮注射液对照组(58例),均辅以常规治疗,治疗3个月,观察两组患者苏醒时间及苏醒成功率,以及GCS及GOS评分改善情况。结果:纳洛酮联合醒脑静注射液治疗组苏醒39例,苏醒率65%,对照组苏醒31例,苏醒率53.4%。治疗组苏醒时间平均为(58.42±13.71)天,较对照组(70.13±15.23)天明显减少(P<0.01)。GOS评分治疗组(4.81±2.19),明显高于对照组(8.37±3.21),(P<0.05)。结论:纳洛酮联合醒脑静注射液治疗重型颅脑损伤长期昏迷病人可明显缩短患者苏醒时间,提高苏醒率,降低病死率及伤残率,改善患者生存质量。
Objective: To investigate the effect of naloxone combined with xingnaojing injection in the treatment of patients with long-term coma after severe craniocerebral injury. Methods: One hundred and eighty-one patients with long-term coma after severe craniocerebral injury were randomly divided into two groups: naloxone combined with xingnaojing injection (n = 60) and naloxone injection alone (n = 58) After 3 months of treatment, the recovery time and recovery success rate of both groups were observed, and the improvement of GCS and GOS scores were observed. Results: Naloxone combined with Xingnaojing injection in the treatment group, 39 cases of awakening, the rate of 65% recovery, the control group, 31 cases wake up, the recovery rate was 53.4%. The recovery time of the treatment group was (58.42 ± 13.71) days, significantly lower than that of the control group (70.13 ± 15.23) days (P <0.01). The GOS score in the treatment group (4.81 ± 2.19) was significantly higher than that in the control group (8.37 ± 3.21), (P <0.05). Conclusion: Naloxone combined with Xingnaojing injection in patients with long-term coma after severe craniocerebral injury can significantly shorten the recovery time, improve the recovery rate, reduce mortality and disability rate, and improve the quality of life of patients.