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目的对2010年云浮市哨点医院手足口病(HFMD)监测结果进行分析,了解云浮市手足口病的病原学特征,为云浮市手足口病的防治提供科学的依据。方法收集73例监测哨点医院手足口病病例送检的粪便标本,应用Real time—PCR技术检测肠道病毒7l型(EV71)、柯萨奇病毒A组16型(CAl6)、非EV7l和CAl6的其它肠道病毒核酸。结果 73例手足口病患者中42例为肠道病毒核酸阳性,阳性率为57.5%,其中EV71病毒、CAl6病毒以及非EV7l和CAl6的其它肠道病毒分别占总阳性数的71.4%、7.1%、21.4%。三种不同型别肠道病毒在全年中交替变更;病毒检出高峰出现在5～6月,病例人群男性高于女性(1.92:1),4岁以下儿童病例阳性率最高。结论云浮市2010年手足口病疫情发病高峰为5-6月,4岁以下儿童病例发病数最多,肠道病毒EV71型是2010年云浮市手足口病流行的主要毒株类型。开展手足口病流行病学和病原学研究,将有助于提出更好的预防和控制措施。
Objective To analyze the monitoring results of hand-foot-mouth disease (HFMD) in sentinel hospital in Yunfu City in 2010 to understand the etiological characteristics of hand-foot-mouth disease in Yunfu City and provide a scientific basis for prevention and treatment of HFMD in Yunfu City. Methods Seventy-three stool samples were collected for the detection of HFMD in sentinel hospitals. Real-time PCR was used to detect EV71, Coxsackie A, type 16 (CA16), non EV71 and CA16 Of other enterovirus nucleic acids. Results Of the 73 HFMD patients, 42 were positive for enterovirus nucleic acid, with a positive rate of 57.5%. Among them, EV71, CAl6 and other enteroviruses other than EV71 and CA16 accounted for 71.4% and 7.1% , 21.4%. The three different types of enteroviruses changed alternately throughout the year. The peak of the virus appeared in May-June. The male of the case group was higher than the female (1.92: 1), and the highest was the case of children under 4 years old. Conclusion The incidence of HFMD in Yunfu in 2010 is from May to June. The number of cases of children under 4 years of age is the most. The EV71 type of enterovirus is the main type of HFMD epidemic in Yunfu in 2010. Developing HFD epidemiology and etiology will help to propose better prevention and control measures.