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RFP复治失败病人,长期排菌,探讨这类病人的治疗,有着临床和流行病学的实际意义。现将我院治疗的疗效总结如下。一、选例标准凡病程在2年以上,经一线药治疗失败,继用RFP等1O个月后痰菌仍阳性,而未用过Z、Th1321的空洞性肺结核,治疗前肝肾功能正常者。五年来共选例53例,因治疗不足半年剔除8例,余下45例供分析。男30例,女15例;有发热症状28例(62.2％),咯血19例(42.2％);病灶<3个肺野13例,≥3个肺野32例。二、化疗方案及方法 12HZ Th1321,即每日用药一年。剂量:体重<50公斤:HO.3g,Z 1.5g,Th1321O.5g;体重≥50公斤:H0.4g,Z 1.75g T.h13210.6g。所有用药都是睡前一次顿服。三、疗效观察 1.细菌学改变:化疗3个月时,痰菌阴转17例(37.8％),6个月时痰菌阴转41例(91.1％)。6个月后痰菌阳性4例,属化疗失败。2.
RFP retreatment failed patients, long-term row bacteria, to explore the treatment of such patients, with clinical and epidemiological practical significance. Now the efficacy of treatment in our hospital are summarized below. First, the selection criteria where the course of disease in more than 2 years, the first-line treatment fails, followed by RFP and other 10 months after the sputum is still positive, but not used Z, Th1321 empty tuberculosis, liver and kidney function before treatment . A total of 53 cases of five years, less than six months due to lack of treatment removed eight cases, the remaining 45 cases for analysis. There were 30 males and 15 females. There were 28 cases (62.2%) with fever, 19 cases (42.2%) with hemoptysis, and 13 cases with <3 lung fields and 32 cases with ≥3 lung fields. Second, chemotherapy regimens and methods 12HZ Th1321, that is, a daily medication. Dosage: weight <50 kg: HO.3g, Z 1.5g, Th1321O.5g; body weight ≥ 50 kg: H0.4g, Z 1.75g T.h13210.6g. All medication is a Dayton clothing before going to bed. Third, the efficacy of observation 1. Bacteriological changes: 3 months of chemotherapy, sputum negative conversion in 17 cases (37.8%), 6 months sputum negative conversion in 41 cases (91.1%). After 6 months sputum positive in 4 cases, is a chemotherapy failure. 2.