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干扰素作用于靶细胞膜表面的受体后,通过信号转导系统诱导一系列抗病毒蛋白产生,干扰病毒复制以达到抗病毒目的。2’-5’寡聚腺苷酸合成酶(2’-5’oligoadenylate synthetase,OAS)是干扰素作用于细胞后产生的一种重要的抗病毒蛋白,几十年来,国内外学者对OAS家族及其抗病毒机制进行了大量研究并取得了一定的进展,OAS被dsRNA激活后,催化生成2-5A,2-5A激活核酸内切酶RNase L,降解病毒RNA,阻断病毒蛋白合成,从而发挥抗病毒作用。体内外研究表明,OAS的表达量或活性的变化可用于评价机体对干扰素的反应,反映干扰素抗病毒效果,另外,它还可作为系统性红斑狼疮的病情活动度的一种检测指标。因此,OAS具有重要的临床应用价值。本文就OAS家族及其抗病毒机制,其测定方法与对于病毒性肝炎和系统性红斑狼疮疾病的临床意义展开综述,以期对OAS的研究和应用提供参考。OAS是典型的干扰素诱导产物,可反映机体内干扰素的抗病毒水平,具有广阔的应用前景。
Interferon acts on the surface of the target cell membrane receptors, induced by a signal transduction system a series of antiviral protein production, interfering with virus replication in order to achieve anti-virus purposes. 2’-5’-oligo-adenylate synthetase (2’-5’-oligoadenylate synthetase) is an important antiviral protein produced by interferon on cells. For decades, And its antiviral mechanism has made a lot of research and made some progress, OAS dsRNA activation, the catalytic generation of 2-5A, 2-5A activation of endonuclease RNase L, degradation of viral RNA, blocking the synthesis of viral proteins, thus Play antiviral effect. In vitro and in vivo studies have shown that changes in the expression or activity of OAS can be used to assess the body’s response to interferon, reflecting the anti-viral effect of interferon, in addition, it can also be used as a measure of disease activity of systemic lupus erythematosus. Therefore, OAS has important clinical value. This article reviews the OAS family and its antiviral mechanism, its determination method and its clinical significance for viral hepatitis and systemic lupus erythematosus, in order to provide reference for the research and application of OAS. OAS is a typical interferon-induced product, which can reflect the antiviral level of interferon in the body and has broad application prospects.