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二价阳离子能诱导脂质体膜的分子重排,失去双层结构,膜稳定性降低,使膜内包裹的红色染料ArsenazoⅢ(AⅢ)释放出来与二价阳离子形成兰色复合物。SLE患者血清中的ANA与脂质体结合后具有屏障作用,将二价阳离子与脂质体膜隔离来保持脂质体膜的稳定性便仍显红色。非SLE患者血清无此作用,则显兰色。材料(1)脂质:棕榈油酰磷脂酰胆硷(POPC)、牛心磷脂和二软脂酰甘油(DPPG)、胆
Divalent cations can induce the molecular rearrangement of liposome membrane, lose the bilayer structure and reduce the membrane stability, release the red dye Arsenazo Ⅲ (A Ⅲ) in the membrane to form blue complex with divalent cation. ANA in serum of SLE patients has a barrier function after binding with liposomes. Isolation of divalent cations from the liposome membrane maintains the stability of the liposome membrane and remains red. Non-SLE serum in patients with no such role, it was blue. Materials (1) Lipids: Palmitoylphosphatidylcholine (POPC), bovine cardiolipin and dipalmitoylglycerol (DPPG), gallbladder