星形细胞瘤CT值与DNA含量及预后的关系

• 作 者: 胡爱祥 孙芳印 常广 翁建康 田立 于德起 张明显
• 机 构: 河北省人民医院神经内科,解放军第４６７医院
• 出 处: 中国体视学与图像分析
• 发表日期: 1997年01期
• 关键词: 星形细胞瘤 CT值 DNA 细胞增殖指数 术后生存期 术后生存时间 强化值 定位诊断 存活时间 星形胶质细胞瘤

ＣＴ扫描技术的应用，大大提高了对脑瘤定位诊断的准确性。但ＣＴ检查能否同时判断肿瘤的大致分级、ＤＮＡ含量（ＤＩ）、细胞增殖指数（ＰＩ）及预后情况，从而更好地为临床提供诊断和治疗依据，这是目前需要探索的一个重要课题。本文对６０例星形细胞瘤的ＣＴ值与其病理分级、ＤＮＡ含量、ＰＩ值以及术后生存期进行了初步研究，结果显示：（１）ＣＴ值与病理分级密切相关，即按病理为Ⅰ、Ⅱ和Ⅲ－Ⅳ级的分组顺序，各组的ＣＴ值逐渐增大；（２）ＣＴ值与ＤＮＡ含量和细胞增殖指数呈正相关关系。即按上述病理分级，各组的ＤＩ和ＰＩ值均随ＣＴ强化（或非强化）值的增大而逐渐增大；（３）ＣＴ值与其预后的关系十分密切，即随ＣＴ值的增高，术后生存时间缩短。在ＣＴ非强化值分别为２９３１±１１９、３９３１±１９１、４６１０±１２２和ＣＴ强化值分别为４０２５±０６０、４４７７±０９９、６５６０±１４６的３组中，其术后存活时间分别为７２、５５和２６个月，呈负相关关系。本研究结果表明，ＣＴ值可以作为推测星形细胞瘤的分级、ＤＮＡ含量水平、细胞增殖程度及术前对预后的综合判断依据，对提高脑瘤的临床诊治水平具有重要参考价值。

The application of CT scanning technology has greatly improved the accuracy of brain tumor localization diagnosis. However, whether the CT examination can determine the approximate grade, DNA content (DI), cell proliferation index (PI) and prognosis of the tumor at the same time, so as to provide a better basis for clinical diagnosis and treatment. This is an important subject that needs to be explored. In this paper, 60 cases of astrocytoma CT and its pathological grade, DNA content, PI value and postoperative survival were studied. The results showed that: (1) CT values ​​and pathological grading are closely related, that according to pathology as I, In the order of group II and III-IV, the CT value of each group gradually increased; (2) CT value was positively correlated with DNA content and cell proliferation index. According to the above pathological classification, the DI and PI values ​​of each group gradually increased with the increase (or non-enhanced) value of CT; (3) the relationship between CT value and its prognosis is very close, that is, with the increase of CT value, Postoperative survival time is shortened. The non-enhanced values ​​on CT were 2931±119, 3931±191, 4610±122, and the CT enhancement values ​​were 4025±060 and 4477±0, respectively. In the three groups of 99,6560±146, the postoperative survival time was 72, 55 and 26 months respectively, showing a negative correlation. The results of this study indicate that the CT value can be used as a presumption of astrocytoma grading, DNA content levels, cell proliferation and preoperative prognosis of comprehensive judgments on the basis of improving the clinical diagnosis and treatment of brain tumors have important reference value.