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NO_2的作用是多方面的,但对其肺外作用研究的较少。为了进一步了解NO_2对健康的全面作用,有必要对NO_2潜在性的全身毒性进行研究。本文是整个研究的第一步,即测定接触不同浓度和时间的NO_2对戊巴比妥诱导的睡眠时间(以下缩写为ST)的影响。药物诱导的ST是公认的测定外源性物质体内代谢的模型,利用此模型得到的浓度和时间资料可为进一步的机理研究提供指导。实验材料和方法:体重18～22g无菌纯种小鼠,雌雄分组。染毒时将小鼠放在特制的不锈钢笼中,NO_2
The role of NO 2 is multifaceted, but there are few studies on its extrapulmonary effects. In order to further understand the full effect of NO 2 on health, it is necessary to study the potential systemic toxicity of NO 2. This article is the first step in the overall study to determine the effect of exposure to different concentrations and times of NO 2 on pentobarbital-induced sleep (hereinafter abbreviated as ST). Drug-induced ST is a well-established model for determining the in vivo metabolism of exogenous substances. Concentration and time data obtained using this model may provide guidance for further mechanistic studies. Experimental Materials and Methods: Sterile purebred mice weighing 18-22g were divided into male and female groups. The mice were placed in a special stainless steel cage when exposed to NO 2