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Objective:To evaluate the relationship between the genetic polymorphism of prostate stem cell antigen(PSCA) and the risk of advanced precancerous gastric lesions including intestinal metaplasia(IM)and dysplasia(Dys),a population-based study was conducted in Linqu County,a high-risk area of gastric cancer(GC)in China. Methods:The prevalence of gastric lesions including superficial gastritis(SG),chronic atrophic gastritis(CAG), IM and Dys was determined by histopathologic examination.The genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)technique.The effects of PSCA genetic variant on the risks of IM and Dys were calculated by unconditional logistic regression. Results:Multivariate analysis revealed subjects carrying PSCA rs2294008 CT/TT genotype were associated with an increased risk of IM(OR=1.38,95%CI=1.11-1.71)and Dys(OR=1.75,95%CI=1.36-2.26),especially for subjects with H.pylori infection(IM:OR=1.34,95%CI=1.05-1.71;Dys:OR=1.82,95%CI=1.37-2.42).Furthermore,H.pylori infection and PSCA rs2294008 CT/TT genotype were observed to jointly elevate the risk of IM(OR=3.32,95% CI=2.33-4.71)and Dys(OR=4.58,95%CI=2.99-7.04). Conclusion:This study suggested that PSCA rs2294008 might have an impact on the risk of IM or Dys among the high risk population of GC.
Objective: To evaluate the relationship between the genetic polymorphisms of prostate stem cell antigen (PSCA) and the risk of advanced precancerous gastric lesions including intestinal metaplasia (IM) and dysplasia (Dys), a population-based study was conducted in Linqu County, a Methods: The prevalence of gastric lesions including superficial gastritis (SG), chronic atrophic gastritis (CAG), IM and Dys was determined by histopathologic examination. The genotypes were determined by polymerase chain Results: Multivariate analysis of subjects carrying carrying PSCA rs2294008 CT / TT genotype were associated with an increased risk of IM (OR = 1.38, 95% CI = 1.11-1.71) and Dys (OR = 1.75, 95% CI = 1.36-2.26), especially for subjects with H. pylori infection (IM: CI = 1.05-1.71; Dys: OR = 1.82,9 5% CI = 1.37-2.42) .Furthermore, H.pylori infection and PSCA rs2294008 CT / TT genotype were observed tovated elevate the risk of IM (OR = 3.32,95% CI = 2.33-4.71) and Dys , 95% CI = 2.99-7.04). Conclusion: This study suggests that PSCA rs2294008 might have an impact on the risk of IM or Dys among the high risk population of GC.