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对五种国产染发剂及其主要组份对苯二胺进行了沙门氏菌致突变（Ａｍｅｓ）试验、小鼠骨髓嗜多染红细胞微核试验的研究，探讨其有无遗传毒性。结果发现４种染发剂和其主要组份对苯二胺在有Ｓ９的条件下，对ＴＡ９７、ＴＡ９８均表现出诱变菌落数大于自发回变数的２倍以上，提示染发剂有一定的遗传毒性，并与对苯二胺的存在有关。微核试验仅１种染发剂在２１．６２ｍｇ／ｋｇ时，微核效应率显著高于对照组（Ｕ＝２．６１，Ｐ＜０．０１）。
Five domestic hair dyes and their main components of phenylenediamine Salmonella mutagenesis (Ames) test, mouse bone marrow polychromatic erythrocyte micronucleus test to explore whether or not genotoxicity. The results showed that 4 kinds of hair dye and its main component of p-phenylenediamine in the S9 conditions, the TA97, TA98 showed more than 2 times the number of induced mutagenesis spontaneous regression, suggesting that the hair dye has some genotoxicity , And the presence of p-phenylenediamine. In the micronucleus test, the micronucleus rate of one hair dye at 21.62mg / kg was significantly higher than that of the control group (U = 2.61, P <0.01).