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Lebrec等在食管曲张静脉出血患者应用心得安后出血机会减少,肝血流量和门脉压显著下降。作者将疗效归因于心输出量减低。但Price等发现,正常人静注大剂量心得安后内脏血流量与心输出量分别下降29%与6%,并认为内脏血流减少较多为舒张血管的β_2受体被阻滞的结果。本文就选择性β_1受体阻滞剂(美多心安)和非选择性β_1β_2受体阻滞剂(心得安)对肝硬化门脉高压症患者心输出量、肝血流量和门脉压的影响进行比较。 18例经活检证实的肝硬化患者,近期均有食管曲
Lebrec et al in patients with esophageal variceal bleeding after the application of safety experience reduced the chance of hepatic blood flow and portal pressure decreased significantly. The authors attribute the efficacy to cardiac output reductions. However, Price et al found that normal subjects had a 29% and 6% reduction in the amount of visceral blood flow and cardiac output after intravenous boluses of high doses and that the reduction of visceral blood flow was the result of the blockade of the β_2 receptor for relaxing blood vessels. In this paper, the effects of selective beta 1 receptor blockers (Metoprolol) and nonselective beta 1 beta 2 blockers (propranolol) on cardiac output, hepatic blood flow and portal pressure in cirrhotic patients with portal hypertension Compare. 18 patients with biopsy confirmed cirrhosis, esophageal recent song