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目的:观察苷必妥治疗慢性乙型肝炎的疗效。方法:84例患者肌注苷必妥,每次1mg,第1～4周每日1次,第5～12周隔日1次,12周为一疗程。结果:患者的临床症状、肝功能有不同程度的改善,总有效率达83.3％。HBsAg阴转率为3.6％,HBeAg阴转率为33.3％,其中11例出现抗HBe阳性,HBV-DNA阴转率为25.0％。10例在治疗前后进行HBV-DNA定量检测,其中9例治疗后HBV-DNA Copies/ml降幅达10～1000倍。结论:苷必妥治疗慢性乙型肝炎有较大的实用价值。
Objective: To observe the effect of glycyrrhizin on chronic hepatitis B. Methods: Eighty-four patients were given intramuscular glycoside once a day for 1 to 4 weeks, once every 5 to 12 weeks and 12 weeks for one course of treatment. Results: The patient’s clinical symptoms and liver function improved to some extent, with a total effective rate of 83.3%. HBsAg negative conversion rate was 3.6%, HBeAg negative conversion rate was 33.3%, of which 11 cases of anti-HBe positive, HBV-DNA negative conversion rate of 25.0%. Ten cases were tested for HBV-DNA quantitatively before and after treatment. Nine cases of HBV-DNA Copies / ml decreased by 10 to 1000 times after treatment. Conclusion: Glycyrrhizin in the treatment of chronic hepatitis B has greater practical value.