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目的评价曲美他嗪对急性心肌梗死患者预后的影响。方法通过对湖南南华大学附属南华医院60例急性心肌梗死患者心肌再灌注和梗死面积及心血管事件的观察,评价曲美他嗪对急性心肌梗死患者预后的影响。结果曲美他嗪治疗组抬高的ST段回落至基线的速率明显快于安慰剂组(P<0.05)。曲美他嗪组Q波消失的发生率较安慰剂组有增加的趋势(10%vs3.3%,P=0.06)。曲美他嗪组心血管事件发生率明显低于安慰剂组(P<0.01)。结论曲美他嗪能有效改善急性心肌梗死患者的预后。
Objective To evaluate the effect of trimetazidine on the prognosis of patients with acute myocardial infarction. Methods The myocardial reperfusion, infarct size and cardiovascular events in 60 patients with acute myocardial infarction in Nanhua Hospital affiliated to Nanhua University in Hunan Province were evaluated to evaluate the effect of trimetazidine on the prognosis of patients with acute myocardial infarction. Results The trimetazidine treatment group had a significantly faster rate of ST elevation to baseline than placebo (P <0.05). The incidence of Q wave disappearance in the trimetazidine group tended to increase compared with placebo (10% vs 3.3%, P = 0.06). The incidence of cardiovascular events in trimetazidine group was significantly lower than that in placebo group (P <0.01). Conclusion Trimetazidine can effectively improve the prognosis of patients with acute myocardial infarction.