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目的通过观察神经节苷脂对急性脑卒中患者的治疗效果及其治疗前后血清中TNF-α和IL-6浓度,探讨神经节苷脂对急性脑卒中患者的治疗作用。方法将2009年1月～2011年1月入住我院的78例急性脑卒中患者随机分为对照组与观察组,对照组给予脑活素治疗,观察组给予神经节苷脂治疗。观察治疗前后患者的FM评分及其血清中TNF-α及IL-6的浓度变化。结果两组患者治疗后的FM评分较其治疗前均明显升高(P<0.05),而观察组患者治疗后的FM评分较对照组治疗后明显升高(P<0.05);两组患者治疗后的血清TNF-α、IL-6浓度较其治疗前均明显降低(P<0.05),而观察组患者治疗后的血清TNF-α、IL-6浓度较对照组治疗后明显降低(P<0.05)。结论神经节苷脂对急性脑卒中患者的治疗效果较好,其作用机制可能为通过降低患者血清中的TNF-α及IL-6的浓度,来保护患者脑神经细胞。
Objective To observe the therapeutic effect of gangliosides in patients with acute stroke and its serum levels of TNF-α and IL-6 before and after treatment, and to explore the therapeutic effect of gangliosides on patients with acute stroke. Methods 78 cases of acute stroke admitted to our hospital from January 2009 to January 2011 were randomly divided into control group and observation group. The control group was treated with cerebrolysin, and the observation group was treated with ganglioside. The changes of FM score and serum TNF-α and IL-6 levels in patients before and after treatment were observed. Results The FM scores of the two groups were significantly higher than those before treatment (P <0.05), while the FM scores of the observation group were significantly higher than those of the control group after treatment (P <0.05) After treatment, the levels of TNF-α and IL-6 in serum of patients in the observation group were significantly lower than those of the control group after treatment (P < 0.05). Conclusion Gangliosides have a good therapeutic effect on patients with acute stroke, and its mechanism may be to protect the brain cells of the patients by decreasing the concentration of TNF-α and IL-6 in the serum.