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目的探讨尿微量白蛋白测定在糖尿病肾病中的诊断作用。方法用免疫散射比浊法测定 １１０例 ２型糖尿病患者和８０例健康人的尿微量白蛋白、尿ｌｇＧ、尿转铁蛋白、尿α１─微球蛋白。所有患者的尿常规检查尿蛋白阴性、肾功能正常。结果尿微量白蛋白在糖尿病患者明显升高（ｐ＜０．００１），随着病程延长，升高愈加明显。病程超过 １０年，尿ｌｇＧ、尿转铁蛋白、尿α１─微球蛋白也升高（ｐ＜ ０． ００１），糖尿病合并高血压者尿微量蛋白升高更明显（ｐ＜ ０．００１）。结论尿微量白蛋白测定对糖尿病肾病变最敏感，合并高血压可加重肾损害。
Objective To investigate the diagnostic value of urinary microalbuminuria in diabetic nephropathy. Methods Urine microalbuminuria, urinary transferrin and urinary α1microglobulin were measured in 110 patients with type 2 diabetes mellitus and 80 healthy people by immune nephelometry. Urine routine examination of all patients urinary protein negative, normal renal function. Results Urine microalbumin in diabetic patients was significantly higher (p <0.001), with the longer duration, the more obvious increase. Course of more than 10 years, urinary lgG, urinary transferrin, urinary α1-microglobulin also increased (p <0.001), diabetes mellitus with elevated urinary microalbumin increased more significantly (p <0.001). Conclusions Urinary microalbuminuria is most sensitive to diabetic nephropathy. Combined hypertension may aggravate renal damage.