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研制了胡椒碱固体脂质纳米粒(SLN),拓展其在口服和皮肤局用方面的应用。采用熔融乳化法制备胡椒碱SLN,以32因子设计法优化处方。结果表明,优化处方的粒径为128.80 nm,包封率为78.71%,ζ电位为-23.34 mV。继续用差示扫描量热
Piperine solid lipid nanoparticles (SLNs) were developed to extend their use in oral and dermal applications. The piperine SLN was prepared by melt-emulsification method and optimized by 32-factor design method. The results showed that the optimal particle size was 128.80 nm, the entrapment efficiency was 78.71% and the zeta potential was -23.34 mV. Continue to use differential scanning calorimetry