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目的分析小剂量甘露醇联合大剂量青霉素治疗神经梅毒的临床效果。方法选取2009年1月—2012年10月我院收治的神经梅毒患者48例,将其随机分为对照组和治疗组,各24例。对照组采用大剂量青霉素治疗,治疗组采用小剂量甘露醇联合大剂量青霉素治疗。比较两组疗效、症状改善时间和实际疗程。结果对照组治疗总有效率为79.2%(19/24),与治疗组的87.5%(21/24)比较,差异无统计学意义(P>0.05)。治疗组症状改善时间和实际疗程均短于对照组(P<0.05)。两组均在接受药敏试验后用药,未出现明显不良反应。结论小剂量甘露醇联合大剂量青霉素治疗神经梅毒临床疗效较满意,能加快患者症状改善时间,并缩短疗程。
Objective To analyze the clinical effect of low dose mannitol combined with high dose penicillin on neurosyphilis. Methods Forty-eight patients with neurosyphilis admitted in our hospital from January 2009 to October 2012 were randomly divided into control group and treatment group, with 24 cases in each group. The control group with high-dose penicillin treatment, the treatment group with low-dose mannitol combined with high-dose penicillin treatment. Compare the two groups efficacy, symptom improvement time and the actual course of treatment. Results The total effective rate of the control group was 79.2% (19/24), which was not significantly different from that of the treatment group (87.5%, 21/24) (P> 0.05). Symptoms of the treatment group to improve the time and the actual treatment were shorter than the control group (P <0.05). Both groups were receiving drug susceptibility test medication, no obvious adverse reactions. Conclusion Small doses of mannitol combined with high-dose penicillin treatment of neurosyphilis clinical efficacy is more satisfactory, can speed up the patient’s symptoms to improve time and shorten the course of treatment.