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目的:探讨前S1抗原在孕妇孕期乙型肝炎血清标志物检查中的价值及临床意义。方法:对11529例孕产妇血清进行乙肝两对半和前S1抗原的检测(ELISA法),如乙肝两对半中一项或以上指标阳性者再用荧光定量PCR法检测HBV-DNA含量,根据检测结果进行统计学分析。结果:880例乙肝两对半抗原阳性孕产妇组中HBeAg、前S1抗原、HBV-DNA阳性率分别为15.68%,54.43%,55.11%,HBeAg阳性率与前S1抗原、HBV-DNA阳性率有统计学意义,而前S1抗原与HBV-DNA阳性率间无统计学意义;6217例抗原阴性抗体阳性孕产妇组中可检出一定比例的前S1抗原(0.53%)和HBV-DNA(0.56%)。结论:前S1抗原作为一种反映HBV复制状态和传染性的指标优于HBeAg。孕妇孕期体检应进行乙肝两对半和前S1抗原的联合检测。
Objective: To investigate the value and clinical significance of pre-S1 antigen in hepatitis B serum markers during pregnancy. Methods: Serum samples from 11,529 pregnant women were tested for the presence of two pairs of HBsAg and preS1 antigen (ELISA). For example, HBsAg was detected by semiquantitative RT-PCR in two or a half of hepatitis B patients. Test results for statistical analysis. Results: The positive rates of HBeAg, pre-S1 antigen and HBV-DNA in 880 HBsAg positive pregnant women were 15.68%, 54.43% and 55.11% respectively. The positive rates of HBeAg and HBV DNA were There was no significant difference between the positive rates of pre-S1 antigen and HBV-DNA in 6217 cases of negative antibody positive pregnant women (0.53%) and HBV-DNA (0.56% ). Conclusions: Pre-S1 antigen is superior to HBeAg as an indicator of HBV replication status and infectivity. Pregnant women during pregnancy should be tested for hepatitis B two and a half and pre-S1 antigen.