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目的:观察六味地黄汤对肥胖高血压大鼠血压的影响,并从胰岛素抵抗及RAS两方面探讨相关机理。方法:40只SD大鼠分为正常组(n=10)及高盐高脂组(n=30)。高盐高脂组予饮食干预两周后分为模型组、中药组及缬沙坦组(均n=10)。每周测大鼠血压,第8周处死大鼠,称体重,检测血脂、血糖、胰岛素浓度,计算胰岛素抵抗指数(HOMA-IR),检测尿醛固酮、尿钾/钠比及血清血管紧张素Ⅱ(AngⅡ)浓度。结果:与正常组相比,模型组大鼠血压、体重明显升高,血脂异常,血糖及HOMA-IR升高;尿醛固酮亦明显升高。与模型组相比,中药组大鼠血压平稳下降;高密度脂蛋白升高;血糖显著降低;HOMA-IR明显下降;尿醛固酮及尿钾/钠明显降低。结论:中药六味地黄汤早期干预能有效降低肥胖高血压大鼠的血压,可能与有效提高胰岛素敏感性及抑制RAS激活有关。
Objective: To observe the effect of Liuwei Dihuang decoction on blood pressure in obese hypertensive rats and to explore its mechanism from the aspects of insulin resistance and RAS. Methods: Forty SD rats were divided into normal group (n = 10) and high salt and high fat group (n = 30). The high-salt and high-fat diet groups were divided into model group, Chinese herb group and Valsartan group (n = 10) two weeks after dietary intervention. The rats were sacrificed on the eighth week after operation. The rats were sacrificed and their body weights were measured. Blood lipids, blood glucose and insulin concentrations were measured. HOMA-IR was calculated. Urinary aldosterone, urinary potassium / sodium ratio and serum angiotensin Ⅱ (Ang Ⅱ) concentration. Results: Compared with the normal group, the blood pressure and body weight of the model group were significantly increased, dyslipidemia, blood glucose and HOMA-IR were increased; urinary aldosterone was also significantly increased. Compared with model group, the blood pressure of rats in TCM group decreased steadily; HDL increased; blood glucose decreased significantly; HOMA-IR decreased significantly; urinary aldosterone and urine potassium / sodium decreased significantly. Conclusion: The early intervention of Liuweidihuang decoction can effectively reduce blood pressure in obese hypertensive rats, which may be related to the improvement of insulin sensitivity and the inhibition of RAS activation.