论文部分内容阅读
采用反相高效液相色谱法测定犬口服芎芍胶囊后阿魏酸的血药浓度 ,以 3P87药代动力学软件拟合药动学模型。结果表明犬灌胃芎芍胶囊后阿魏酸的体内过程符合开放性一室模型 ,测得药代参数为Ⅰ级吸收速度常数 =0 0 74 9± 0 0 2 0 2 (min- 1) ,Ⅰ级消除速度常数 =0 0 159± 0 0 0 2 0(min- 1) ,半吸收期 =9 73± 2 38(min) ,半衰期 =4 4 2 5± 5 52 (min) ,达峰时间 =2 9 39± 4 10(min) ,血药峰浓度 =150 9 52± 2 75 81(μg/L)。为临床合理用药提供了实验依据。
The plasma concentration of ferulic acid was determined by reversed-phase high-performance liquid chromatography (HPLC) after oral administration of canine capsules. The pharmacokinetic model was fitted by 3P87 pharmacokinetic software. The results showed that the in vivo process of ferulic acid in dogs after oral administration of capsules was consistent with the open one-compartment model. The measured pharmacokinetic parameters were grade I absorption rate constants of 0 0 74 9± 0 0 2 0 2 (min-1). Class I elimination rate constant = 0 0 159 ± 0 0 0 2 0 (min-1), half-absorption period = 9 73 ± 2 38 (min), half-life = 4 4 2 5 ± 5 52 (min), peak time = 2 9 39 ± 4 10 (min), peak plasma concentration = 150 9 52 ± 2 75 81 (μg/L). It provides experimental basis for clinical rational drug use.