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目的分析硫酸镁联合硝苯地平治疗妊娠期高血压的临床疗效。方法选取2013年12月—2015年12月新疆医科大学第二附属医院收治的妊娠期高血压患者136例,采用随机数字表法分为对照组和观察组,每组68例。在常规治疗基础上,对照组患者给予硫酸镁治疗,观察组患者在对照组基础上给予硝苯地平缓释片治疗;两组患者均连续治疗3 d。结果观察组患者临床疗效优于对照组(P<0.05)。两组患者治疗前收缩压、舒张压比较,差异无统计学意义(P>0.05);观察组患者治疗后收缩压、舒张压均低于对照组(P<0.05)。观察组患者治疗期间并发症发生率低于对照组(P<0.05)。观察组患者胎儿早产、产后出血、胎儿窘迫发生率及低出生体质量胎儿所占比例均低于对照组(P<0.05)。结论硫酸镁联合硝苯地平缓释片治疗妊娠期高血压的临床疗效确切,能有效降低并发症发生率,改善妊娠结局。
Objective To analyze the clinical efficacy of magnesium sulfate combined with nifedipine in the treatment of gestational hypertension. Methods 136 patients with gestational hypertension admitted to the Second Affiliated Hospital of Xinjiang Medical University from December 2013 to December 2015 were randomly divided into control group and observation group with 68 cases in each group. On the basis of routine treatment, patients in the control group were treated with magnesium sulfate. Patients in the observation group were given nifedipine sustained-release tablets on the basis of the control group. Patients in both groups were treated continuously for 3 days. Results The clinical efficacy of the observation group was better than that of the control group (P <0.05). Before treatment, systolic blood pressure and diastolic blood pressure were not significantly different between the two groups (P> 0.05). Systolic blood pressure and diastolic blood pressure were lower in the observation group than those in the control group (P <0.05). The incidence of complications in observation group was lower than that in control group (P <0.05). The fetus preterm birth, postpartum hemorrhage, fetal distress rate and the proportion of low birth weight fetuses in observation group were lower than those in control group (P <0.05). Conclusion Magnesium sulfate combined with nifedipine sustained release tablets in the treatment of gestational hypertension clinical curative effect can effectively reduce the incidence of complications and improve pregnancy outcomes.