NF-κB在胶质瘤细胞凋亡中的作用

• 作 者: 姚轶群 崔承志 徐英辉 罗其中
• 机 构: 大连医科大学附属第一医院神经外科,大连医科大学附属第一医院神经外科,大连医科大学附属第一医院神经外科,大连医科大学附属第一医院神经外科 116011,116011,116011,116011
• 出 处: 国际神经病学神经外科学杂志
• 发表日期: 2007年01期
• 关键词: NF-κB 胶质瘤 凋亡

NF-κB蛋白家族作为转录调控因子,参与细胞的增殖、抑制细胞的凋亡,并被证实和许多肿瘤的形成有关,在肿瘤发生发展过程中具有重要作用。近年来研究发现NF-κB与胶质瘤的恶性程度、侵袭性、血管生成密切相关,NF-κB通路介导了肿瘤相关基因的异常表达,从而抑制胶质瘤细胞凋亡,促进胶质瘤血管形成和转移等,直接影响胶质瘤的发生和发展,而降低胶质瘤中NF-κB的活性有可能成为治疗胶质瘤的新方向。

As a transcriptional regulator, NF-κB family of proteins is involved in the proliferation of cells and inhibits the apoptosis of cells. It has been proved that NF-κB is involved in the formation of many tumors and plays an important role in tumorigenesis. In recent years, it has been found that NF-κB is closely related to the malignancy, invasiveness and angiogenesis of gliomas, and the NF-κB pathway mediates the abnormal expression of tumor-related genes, thereby inhibiting glioma cell apoptosis and promoting glioma Vascular formation and metastasis, directly affect the occurrence and development of glioma, and reduce the activity of NF-κB in glioma may become a new direction for the treatment of glioma.