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目的探讨影响神经系统副肿瘤综合征(paraneoplastic syndromes of the nerve system,PNSNS)预后的相关因素。方法在回顾分析中所有病例来源于徐州地区2002年1月～2005年5月就诊于神经科和肿瘤科的 PNSNS 患者,共31例。经过抗肿瘤治疗后追踪观察其神经系统牛津残障评分(OHS)的改善情况。在单因素分析的基础上应用非条件 logistic 回归分析技术,对治疗有效和无效的 PNSNS 病人的相关因素进行分析。结果分析显示在α=0.05的水平上,筛选出3个对于 PNSNS 治疗后神经系统改善有统计学意义的独立影响因素:即年龄、抗体滴度、OHS 评分。结论 PNSNS 患者发病时年龄、抗体滴度和 OHS 评分直接影响患者的预后。年龄大于60岁、抗体滴度大于1:4000、OHS 评分大于3均提示预后不良。
Objective To investigate the related factors affecting the prognosis of paraneoplastic syndromes of the nerve system (PNSNS). Methods In retrospective analysis, all cases were from PNSNS patients in neurology and oncology in Xuzhou from January 2002 to May 2005, a total of 31 cases. After anti-tumor therapy follow-up to observe the improvement of the nervous system Oxford disability score (OHS). On the basis of univariate analysis, non-conditional logistic regression analysis was used to analyze the related factors of effective and ineffective PNSNS patients. Results analysis showed that at the level of α = 0.05, three independent influencing factors for the improvement of nervous system after PNSNS treatment were selected: age, antibody titer and OHS score. Conclusions The age, antibody titers and OHS scores of patients with PNSNS directly affect the prognosis of patients. Patients older than 60 years, antibody titers greater than 1: 4000, and OHS scores greater than 3 indicate a poor prognosis.