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提高抗肿瘤药的治疗效果有三种方法:一是临床采用联合用药,以改进给药方案;二是用制剂技术改变药物在体内的动力学和剂量-效应的相关性,提高药物的治疗指数;三是寻找新的抗肿瘤药。在新药寻找及制剂研究过程中,常常遇到药剂学问题,如稳定性、溶解性等。我们的观点是开发简单的给药系统来解决若干抗肿瘤药的制剂问题。本文讨论改善药物溶解度和稳定性的方法。Ⅰ.抗肿瘤药物存在的问题影响许多有希望的抗肿瘤药进一步开发的主要制剂问题,是其稳定性差,水溶性不良,膜通透性差。而这些因素是理想制剂的
There are three ways to improve the therapeutic effect of antitumor drugs: one is to use combination therapy in clinic to improve the dosing regimen; the other is to use the technology of formulation to change the correlation between the kinetics and dose-effect of drugs in the body and improve the therapeutic index of drugs; The third is to find new anti-cancer drugs. In the search for new drugs and preparation of the study process, often encountered pharmaceutical problems, such as stability, solubility and so on. Our point is to develop a simple drug delivery system to solve the formulation problem of several antineoplastic agents. This article discusses ways to improve drug solubility and stability. I. Problems Existing in Antitumor Drugs The major problem affecting the development of many promising antitumor drugs is their poor stability, poor water solubility and poor membrane permeability. These factors are ideal formulations