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目的探讨精神心理、职业和饮食习惯对恶性肿瘤发病的影响程度,为制定恶性肿瘤的预防策略提供科学依据。方法调查2010—2012年新发恶性肿瘤患者2 471人,按性别相同、年龄±5岁1∶1匹配选取健康人群2 471人。调查数据采用单因素和多因素条件Logistic回归进行分析。结果单因素条件Logistic回归分析检出12个相关因素。多因素条件Logistic回归分析显示有害职业史(OR=1.731,95%CI:1.337～2.242)、常吃腌制蔬菜、煎炸烹饪(OR=1.889,95%CI:1.398～2.551)、重盐饮食(OR=1.457,95%CI:1.169～1.818),婚姻生活差(OR=2.007,95%CI:1.111～3.623)、精神压抑(OR=1.274,95%CI:1.003～1.617)和缺乏自我调节(OR=1.460,95%CI:1.189～1.793)等7项因素为恶性肿瘤的独立危险因素,与恶性肿瘤发病有关。结论桐乡市恶性肿瘤的发病与多种暴露因素有关,精神心理因素已成为重要的危险因素之一。
Objective To explore the impact of mental health, occupation and eating habits on the incidence of malignant tumors and to provide a scientific basis for the development of preventive strategies for malignant tumors. Methods A total of 2 471 newly diagnosed patients with malignant tumors were recruited from 2010 to 2012. A total of 2 471 healthy individuals were selected according to the gender 1: 1 age ± 5 years old. Survey data using univariate and multivariate conditional logistic regression analysis. Results Single factor conditional logistic regression analysis detected 12 related factors. Multivariate Logistic regression analysis showed that harmful occupational history (OR = 1.731, 95% CI: 1.337-2.242), eating pickled vegetables, fried cooking (OR = 1.889,95% CI: 1.398-2.551), heavy salt diet (OR = 1.457, 95% CI: 1.169-1.818), poor marital life (OR = 2.007, 95% CI: 1.111-3.623), depression (OR = 1.274, 95% CI: 1.003-1.617) and lack of self-regulation (OR = 1.460, 95% CI: 1.189-1.793) were independent risk factors for malignant tumors, which were related to the incidence of malignant tumors. Conclusions The incidence of malignant tumors in Tongxiang is related to various exposure factors. Psychological factors have become one of the important risk factors.