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目的探讨早期妊娠者尿液中完整型人绒毛膜促性腺激素(i-hC G)及其相关蛋白(hC GRP)比值预测先兆流产妊娠结局的价值。方法选择2015年1月-12月金华市妇幼保健院妇科先兆流产患者100例为观察组,正常早孕女性100例作为对照组。观察组根据保胎结局分为观察组A(先兆流产保胎成功)和观察组B(先兆流产保胎失败)。采用InE xscreen检测试剂盒检测尿i-hC G和hC GRP比值。结果观察组B尿i-hC G水平秩均值(29.57)明显低于观察组A(113.14)和对照组(116.38),各组间比较,差异有统计学意义(P<0.05),观察组A和对照组尿i-hC G水平秩均值比较,差异无统计学意义(P>0.05)。观察组B尿i-hC G/hC GRP阳性2的比例明显高于观察组A和对照组(P<0.05),观察组A和对照组尿i-hC G/hC GRP阳性1及阳性2比较,差异无统计学意义(P>0.05)。观察组A和对照组子痫前期、早产及胎盘早剥的发生率比较,差异无统计学意义(P>0.05)。两组分娩孕周和新生儿出生体质量比较,差异无统计学意义(P>0.05)。尿i-hC G/hC GRP阳性2诊断先兆流产保胎失败的灵敏度为100%,特异度为80.5%,阳性预测值为52.9%,阴性预测值为100%,假阳性率为19.5%,假阴性率为0。结论尿i-hC G/hC GRP比值对先兆流产保胎结局有一定的预测价值,尿i-hC G/hC GRP阳性2预测先兆流产保胎失败的灵敏度、特异度和正确指数较高。
Objective To investigate the value of i-hCG and hC-GRP in the urine of early pregnancy to predict the outcome of threatened abortion. Methods 100 cases of gynecological threatened abortion in Jinhua Maternal and Child Health Hospital from January to December in 2015 were selected as observation group and 100 normal pregnant women as control group. The observation group was divided into observation group A (successful threatened abortion) and observation group B (failed threatened miscarriage) according to the miscarriage outcomes. Urinary i-hC G and hC GRP ratios were measured using InE xscreen detection kit. Results The mean rank of urine i-hC G in observation group B (29.57) was significantly lower than that in observation group A (113.14) and control group (116.38), and the difference was statistically significant (P <0.05) There was no significant difference in urinary i-hC G level and control group (P> 0.05). The ratio of urinary i-hC G / hC GRP positive 2 in observation group B was significantly higher than that in observation group A and control group (P <0.05). The urine i-hC G / hC GRP positive 1 and positive 2 in observation group A and control group , The difference was not statistically significant (P> 0.05). The incidence of preeclampsia, premature birth and placental abruption in observation group A and control group had no significant difference (P> 0.05). There was no significant difference in birth weight between two groups of gestational age and newborn (P> 0.05). Urine i-hC G / hC GRP-positive 2 The diagnostic sensitivity to 100% failed vaginal miscarriage failure was 80.5%, with a positive predictive value of 52.9%, a negative predictive value of 100%, a false positive rate of 19.5%, a false positive rate of 19.5% Negative rate of 0. Conclusion The urinary i-hC G / hC GRP ratio has certain predictive value for the outcome of pregnancy-induced abortion. The sensitivity, specificity and correctness index of urinary i-hC G / hC GRP-positive 2 in predicting failure of threatened abortion miscarriage are higher.