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目的:观察替米沙坦联合非洛地平治疗原发性高血压左心室肥厚的作用。方法:86例原发性高血压合并左心室肥厚的患者随机分成2组,治疗组(n=43)给以替米沙坦联合非洛地平治疗,对照组(n=43)单用非洛地平治疗。2组均给药30周后,观测收缩压、舒张压、心率、左心室舒张末期室间隔厚度(IVST)、左心室后壁厚度(LVPWT)、左心室舒张末期内径(LVDd)和左心室重量指数(LVMI)的变化。结果:治疗30周后,治疗组与对照组的收缩压、舒张压均较治疗前均明显下降(P<0.01),两组的IVST、LVPWT、LVDd及LVMI均明显低于治疗前(P<0.05或0.01);治疗后,治疗组的收缩压、舒张压较对照组明显下降(P<0.01),IVST、LVPWT、LVDd及LVMI也较对照组有明显下降(P<0.05或0.01)。结论:替米沙坦联合非洛地平不仅能有效控制高血压,而且能够逆转高血压引起的左心室肥厚。
Objective: To observe the effect of telmisartan and felodipine on left ventricular hypertrophy in patients with essential hypertension. Methods: A total of 86 patients with essential hypertension complicated with left ventricular hypertrophy were randomly divided into two groups. The treatment group (n = 43) was given telmisartan combined with felodipine. The control group (n = 43) Treatment of the horizon. Systolic blood pressure, diastolic blood pressure, heart rate, left ventricular end diastolic interventricular septum thickness (IVST), left ventricular posterior wall thickness (LVPWT), left ventricular end-diastolic diameter (LVDd) and left ventricular weight Index (LVMI) changes. Results: After 30 weeks of treatment, the systolic and diastolic blood pressure in treatment group and control group were significantly lower than those before treatment (P <0.01), and the IVST, LVPWT, LVDd and LVMI in both groups were significantly lower than those before treatment (P < 0.05 or 0.01). After treatment, the systolic pressure and diastolic pressure of the treatment group were significantly lower than those of the control group (P <0.01), and the levels of IVST, LVPWT, LVDd and LVMI were also significantly decreased (P <0.05 or 0.01). Conclusion: Telmisartan combined with felodipine can not only effectively control hypertension, but also reverse hypertension-induced left ventricular hypertrophy.