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目的 探讨蜂胶对诱变剂诱发染色体损伤的保护作用。方法 应用小鼠骨髓微核试验及胎肝微核试验检测蜂胶对环磷酰胺诱发微核形成的抑制作用。结果 骨髓微核试验发现 50 0mg/kg ,2 0 0 0mg/kg和 80 0 0mg/kg 3个蜂胶剂量对环磷酰胺引起的微核发生率均产生明显的抑制作用 (F =77.83 ,P =0 .0 0 0 ) ,抑制率分别为 55.98% ,66.67%和 82 .0 5% .胎肝微核试验示 3个蜂胶剂量同样显示出明显的抑制作用 (F =2 0 1.0 2 ,P =0 .0 0 0 ) ,抑制率分别为 3 9.0 2 % ,64 .77%和 83 .4 7% .结论 蜂胶对环磷酰胺诱发的小鼠染色体损伤有较强的抑制作用
Objective To investigate the protective effect of propolis on chromosomal damage induced by mutagens. Methods Mouse bone marrow micronucleus test and fetal liver micronucleus test were used to detect the inhibitory effect of propolis on micronucleus formation induced by cyclophosphamide. RESULTS: Bone marrow micronucleus test showed that three propolis doses of 500 mg/kg, 200 mg/kg and 800 mg/kg significantly inhibited the incidence of micronucleus caused by cyclophosphamide (F = 77.83 , P = 0. 0 0 0), the inhibition rates were 55.98%, 66.67% and 82.05%, respectively. The fetal liver micronucleus test showed that 3 propolis doses also showed significant inhibitory effects (F = 2 0 1.0 2 , P = 0. 0 0 0 ), the inhibition rates were 3 9.0 2%, 64.77% and 83.47% respectively. Conclusion Propolis has a strong inhibitory effect on cyclophosphamide-induced chromosome damage in mice.