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目的研究常规治疗剂量和高剂量90Sr照射对血管壁平滑肌的生物学效应。方法18只新西兰兔分为3组,行髂动脉内膜剥脱术后,12只用90Sr后装技术行血管内照射,距放射源中心轴线2mm深度血管壁吸收剂量分别为16和50Gy,6只未行血管内照射治疗作为对照组。28d后处死动物进行组织病理学分析。结果50Gy组血管中层组织为类内皮样细胞所覆盖,其血栓发生率(36只)高于对照组(06只)和16Gy组(16只)。16Gy组狭窄指数、增殖指数、增殖细胞核抗原阳性率和凋亡细胞阳性率与对照组比较差异有显著性。50Gy组狭窄指数、增殖指数与对照组和16Gy组比较,差异均有显著性。结论16Gy组血管内膜增生受到明显抑制,剂量增加到50Gy时,内膜增生现象完全受到抑制,除血栓发生率较高外,未见其他如假性动脉瘤等血管严重并发症。
Objective To study the biological effects of conventional therapy and high-dose 90Sr irradiation on vascular smooth muscle. Methods Twenty-eight New Zealand rabbits were divided into 3 groups. After iliac arterial endarterectomy, 12 rabbits were treated with 90Sr after-loading technique, and the absorbed dose of vascular wall at 2mm from the central axis of the radioactive source was 16 and 50 Gy, respectively No intravascular irradiation as a control group. Animals were sacrificed 28 days later for histopathological analysis. Results The middle vascular tissue of the 50Gy group was covered by endothelium-like cells. The incidence of thrombosis in the 50Gy group was higher than that in the control group (06) and 16Gy group (16). The stenosis index, proliferation index, proliferating cell nuclear antigen positive rate and apoptotic cell positive rate in 16Gy group were significantly different from those in control group. 50Gy group stenosis index, proliferation index compared with the control group and 16Gy group, the difference was significant. Conclusion The intimal hyperplasia of 16Gy group was significantly inhibited. When the dose was increased to 50Gy, the intimal hyperplasia was completely inhibited and no other serious vascular complications such as pseudoaneurysm were found except for the high incidence of thrombosis.