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本文报道150名HBsAg阴性产妇所生新生儿在实施计划免疫的同时,1、2组分别接种10μg、20μg乙肝疫苗,3组不接种乙肝疫苗,以了解乙肝疫苗与卡介苗、百白破联合免疫的免疫应答。结果表明:1.2组抗-HBc达到有效保护的(P/N≥5)为93.18％和89.58％,无显著差异;两组均未检出HBV标志物,但是未注射乙肝疫苗组HBV感染达6.67％。乙肝疫苗与卡介苗、百白破联合免疫应答是好的,抗原间无干扰,从而证明乙肝疫苗不但能有效地控制乙型肝炎,并能纳入扩大免疫规划。
This article reports 150 newborns born of HBsAg-negative mothers in the implementation of the planned immunization at the same time, 1, 2 were inoculated with 10μg, 20μg of hepatitis B vaccine, 3 were not vaccinated to understand hepatitis B and BCG vaccine, diphtheria combined immunization Immune response. The results showed that there was no significant difference between the two groups (P / N≥5) of 93.18% and 89.58%, respectively. HBV markers were not detected in both groups, but the HBV infection in non-HBV group was 6.67 %. Hepatitis B vaccine combined with BCG vaccine and diphtheria combined immune response are good with no interference between the antigens, which proves that hepatitis B vaccine can not only effectively control hepatitis B, but also can be included in the expanded immunization program.